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Article

MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma

8 Jun 2017

Abstract excerpt

Renal carcinoma is a common and aggressive malignancy whose histopathogenesis is incompletely understood and that is largely resistant to cytotoxic chemotherapy. We present two mouse models of kidney cancer that recapitulate the genomic alterations found in human papillary (pRCC) and clear cell RCC (ccRCC), the most common RCC subtypes. MYC activation results in highly penetrant pRCC tumours (MYC), while MYC...

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PMID: 28593993
DOI: 10.1038/ncomms15770

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