Article
Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America - 18 Nov 2014
Wang Shan-Shan, Gu Yi-Feng, Wolff Nicholas, Stefanius Karoliina, Christie Alana, Dey Anwesha, Hammer Robert E, Xie Xian-Jin, Rakheja Dinesh, Pedrosa Ivan, Carroll Thomas, McKay Renée M, Kapur Payal, Brugarolas James
Abstract excerpt
Why different species are predisposed to different tumor spectra is not well understood. In particular, whether the physical location of tumor suppressor genes relative to one another influences tumor predisposition is unknown. Renal cancer presents a unique opportunity to explore this question. Renal cell carcinoma (RCC) of clear-cell type (ccRCC), the most common type, begins with an intragenic mutation in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.