Article

Abolished frameshifting for predicted structure-stabilizing SARS-CoV-2 mutants: Implications to alternative conformations and their statistical structural analyses

2024-03-29

Abstract excerpt

The SARS-CoV-2 frameshifting element (FSE) has been intensely studied and explored as a therapeutic target for coronavirus diseases including COVID-19. Besides the intriguing virology, this small RNA is known to adopt many length-dependent conformations, as verified by multiple experimental and computational approaches. However, the role these alternative conformations play in the frameshifting mechanism and how t...

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Literature Corpus work: 37c22726-b7e5-5ff2-8436-e1b3be385ca3
DOI: 10.1101/2024.03.28.586935

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