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Article

Abolished frameshifting for predicted structure-stabilizing SARS-CoV-2 mutants: implications to alternative conformations and their statistical structural analyses.

RNA (New York, N.Y.) - 16 Oct 2024

Dey Abhishek, Yan Shuting, Schlick Tamar, Laederach Alain

Abstract excerpt

The SARS-CoV-2 frameshifting element (FSE) has been intensely studied and explored as a therapeutic target for coronavirus diseases, including COVID-19. Besides the intriguing virology, this small RNA is known to adopt many length-dependent conformations, as verified by multiple experimental and computational approaches. However, the role these alternative conformations play in the frameshifting mechanism and how...

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Identifiers

PMID: 39084880
DOI: 10.1261/rna.080035.124
PMCID: PMC11482603

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