Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polo‐like‐kinase 1 is a proviral host factor for hepatitis B virus replication

26 Apr 2017

Abstract excerpt

Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC) and current treatments for chronic hepatitis B and HCC are suboptimal. Herein, we identified cellular serine/threonine Polo‐like‐kinase 1 (PLK1) as a positive effector of HBV replication. The aim of this study was to demonstrate the proviral role of PLK1 in HBV biosynthesis and validate PLK1 inhibition a potential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriophages and microbial interactions
Share to Hepatitis B Virus Studies
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28445592
DOI: 10.1002/hep.29236

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polo‐like‐kinase 1 is a proviral host factor for hepatitis B virus replicationPMID 28445592Read ↗

Identification of Cyclin L1 as a host factor regulating Hepatitis B Virus replicationSemantic proximity Read ↗

Deciphering the phospho-signature induced by hepatitis B virus in primary human hepatocytesSemantic proximity Read ↗

Analysis of Host Factor Networks during Hepatitis B Virus Infection in Primary Human HepatocytesSemantic proximity Read ↗

THE DUAL-SPECIFICITY KINASE DYRK1A INTERACTS WITH THE HEPATITIS B VIRUS GENOME AND REGULATES THE PRODUCTION OF VIRAL RNASemantic proximity Read ↗

Evaluation of PRKACA as a Therapeutic Target for Fibrolamellar CarcinomaSemantic proximity Read ↗

Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systemsSemantic proximity Read ↗

Polo‐like kinase 4 inhibitor CFI‐400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunitySemantic proximity Read ↗

Plasma levels of sPD-1 and PD-1 genetic variants are associated with hepatitis B infection and related liver disease progressionSemantic proximity Read ↗

Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma.Semantic proximity Read ↗

The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice.Semantic proximity Read ↗

HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice.Semantic proximity Read ↗

Circulating level of sPD-1 and PD-1 genetic variants are associated with hepatitis B infection and related liver disease progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.