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Hereditary Renal Cancer Syndromes: Clinicopathologic Features and Correlation With Tumors Harboring Somatic Mutations.

Advances in anatomic pathology - 1 Mar 2026

Cornejo Kristine M, Machacek Miranda E, Lu Zhichun, Campos Clemente Leticia, Liu Xiaoyang, Nair Varsha, Wu Chin-Lee

Abstract excerpt

Hereditary renal cancer syndromes account for approximately 5% to 8% of all renal cell carcinomas (RCCs) and are caused by germline alterations, mainly in tumor suppressor genes. Advances in molecular testing have led to the identification of new hereditary syndromes and expanded our understanding of the genetic landscape of renal neoplasia. This review summarizes both well-established and recently described...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41622805
DOI: 10.1097/PAP.0000000000000521

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