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Germline Susceptibility to Renal Cell Carcinoma and Implications for Genetic Screening.

JCO precision oncology - 1 Jul 2024

Glennon Kate I, Endo Mikiko, Usui Yoshiaki, Iwasaki Yusuke, Breau Rodney H, Kapoor Anil, Lathrop Mark, Tanguay Simon, Momozawa Yukihide, Riazalhosseini Yasser

Abstract excerpt

PURPOSE: Genetic susceptibility to nonsyndromic renal cell carcinoma (RCC) remains poorly understood, especially for different histological subtypes, as does variations in genetic predisposition in different populations. The objectives of this study were to identify risk genes for RCC in the Canadian population, investigate their clinical significance, and evaluate variations in germline pathogenic variants (PVs)...

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Aged
Canada
Carcinoma, Renal Cell
FH gene
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Testing

Germ-Line Mutation

Kidney Neoplasms

Source

Identifiers

PMID: 39088769
DOI: 10.1200/PO.24.00094

Genes

ATM
CHEK2
FH
BRCA1
BAP1
BRCA2
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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