Article

The genetic architecture of the human skeletal form

2023-01-03

Abstract excerpt

The human skeletal form underlies our ability to walk on two legs, but unlike standing height, the genetic basis of limb lengths and skeletal proportions is less well understood. Here we applied a deep learning model to 31,221 whole body dual-energy X-ray absorptiometry (DXA) images from the UK Biobank (UKB) to extract 23 different image-derived phenotypes (IDPs) that include all long bone lengths as well as hip a...

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Literature Corpus work: 375db843-2dfb-57d4-a6bc-1b5e29c12114
DOI: 10.1101/2023.01.03.521284

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