Article

SFRP1 Decreases Wnt-Mediated M2 Macrophage Marker Expression in Breast Tissue

2023-12-13

Abstract excerpt

The Wnt family of secreted proteins are involved in mammary gland development and tumorigenesis. It has recently been shown that Wnt ligands promote M2 macrophage polarization and so we sought to determine the effects of a Wnt signaling antagonist, Secreted Frizzled Related Protein 1 (SFRP1), on M2 marker expression. We measured a murine M2 marker ( Arg1 ) in mice with a targeted deletion of Sfrp 1 during differen...

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Literature Corpus work: 3720d6ff-9d39-5825-b014-ed7a4b2d5f54
DOI: 10.21203/rs.3.rs-3726599/v1

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