SLITs Suppress Tumor Growth <i>In vivo</i> by Silencing <i>Sdf1/Cxcr4</i> within Breast Epithelium

Abstract excerpt

The genes encoding Slits and their Robo receptors are silenced in many types of cancer, including breast, suggesting a role for this signaling pathway in suppressing tumorigenesis. The molecular mechanism underlying these tumor-suppressive effects has not been delineated. Here, we show that loss of Slits, or their Robo1 receptor, in murine mammary gland or human breast carcinoma cells results in coordinate...

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