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Identification of key interactions of benzimidazole resistance-associated amino acid mutations in <i>Ascaris</i> β-tubulins by molecular docking simulations

2021-11-04

Abstract excerpt

Ascaris species are soil-transmitted helminths that infect humans and livestock mainly in low and middle-income countries. Benzimidazole (BZ) class drugs have predominated for many years in the treatment of Ascaris infections, but persistent use of BZs has already led to widespread resistance in other nematodes, and treatment failure is emerging for Ascaris . Benzimidazoles act by binding to β-tubulin proteins a...

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Literature Corpus work
36903637-c480-51e4-98a9-1daea111b1cb
DOI
10.1101/2021.11.03.467184
Open publication

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Identification of key interactions of benzimidazole resistance-associated amino acid mutations in <i>Ascaris</i> β-tubulins by molecular docking simulationsDOI 10.1101/2021.11.03.467184
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