Evaluating beta-tubulin variants as predictors of benzimidazole resistance across Caenorhabditis nematodes.

doi:10.1371/journal.ppat.1014306

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Evaluating beta-tubulin variants as predictors of benzimidazole resistance across Caenorhabditis nematodes.

PLoS pathogens - 1 Jun 2026

Shaver Amanda O, McKeown Ryan, Reyes Otero Joyce M, Collins J B, Hogan Daniel W, Fraser James S, Dreyer Stephen M, Ragsdale Erik J, Andersen Erik C

Abstract excerpt

Benzimidazoles, a widely used class of anthelmintic drugs, target beta-tubulin, disrupt microtubule formation, and delay nematode development. In parasitic nematodes, mutations in beta-tubulin genes are predicted to inhibit benzimidazole binding and are associated with resistance. In the free-living nematode Caenorhabditis elegans, loss-of-function mutations in the beta-tubulin gene ben-1 cause benzimidazole...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anthelmintics
Share to Benzimidazoles
Share to Caenorhabditis
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Drug Resistance

Share to Mutation

Share to Tubulin

Source

Open in PubMed Open full text

Identifiers

PMID: 42247472
DOI: 10.1371/journal.ppat.1014306
PMCID: PMC13262929

Provenance

PubMed metadata and Literature Corpus relationships.