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Article

Towards the identification of the binding site of benzimidazoles to β-tubulin of Trichinella spiralis: insights from computational and experimental data.

Journal of molecular graphics & modelling - 1 Apr 2013

Aguayo-Ortiz Rodrigo, Méndez-Lucio Oscar, Medina-Franco José L, Castillo Rafael, Yépez-Mulia Lilián, Hernández-Luis Francisco, Hernández-Campos Alicia

Abstract excerpt

Benzimidazole-2-carbamate derivatives (BzC) are among the most important broad-spectrum anthelmintic drugs for the treatment of nematode infections. BzC selectively bind to the β-tubulin monomer and inhibit microtubule polymerization. However, the crystallographic structure of the nematode tubulin and the mechanism of action are still unknown. Moreover, the relation between the mechanism of action and the binding...

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PMID: 23454612
DOI: 10.1016/j.jmgm.2013.01.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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