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Article

In vitro selection of Giardia duodenalis for Albendazole resistance identifies a β-tubulin mutation at amino acid E198K.

International journal for parasitology. Drugs and drug resistance - 1 Aug 2021

Emery-Corbin Samantha J, Su Qiao, Tichkule Swapnil, Baker Louise, Lacey Ernest, Jex Aaron R

Abstract excerpt

Benzimidazole-2-carbamate (BZ) compounds, including Albendazole (Alb), are one of just two drug classes approved to treat the gastrointestinal protist Giardia duodenalis. Benzimidazoles bind to the tubulin dimer interface overlapping the colchicine binding site (CBS) of β-tubulin, thereby inhibiting microtubule polymerisation and disrupting microtubule networks. These BZ compounds are widely used as anthelmintic,...

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Identifiers

PMID: 34237690
DOI: 10.1016/j.ijpddr.2021.05.003
PMCID: PMC8267433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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