Article

Chemical Inhibition of Mitochondrial Fission Improves Mitochondrial Function and Subdues Hyperglycemia Induced Stress in Placental Trophoblast Cells

2022-06-03

Abstract excerpt

Gestational diabetes mellitus (GDM) is a metabolic complication that affects millions of pregnant women in the world. Placental tissue function is endangered by hyperglycemia during GDM, which is correlated to increased incidences of pregnancy complications. Recently we showed that due to a significant decrease in mitochondrial fusion, mitochondrial dynamics equilibrium is altered in placental tissues from GDM pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 367ff7e0-3040-5334-9ee5-85be5ac61812
DOI: 10.21203/rs.3.rs-1706968/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chemical Inhibition of Mitochondrial Fission Improves Mitochondrial Function and Subdues Hyperglycemia Induced Stress in Placental Trophoblast CellsDOI 10.21203/rs.3.rs-1706968/v1Read

Dichotomy in hypoxia-induced mitochondrial fission in placental mesenchymal cells during development and preeclampsia: consequences for trophoblast mitochondrial homeostasisSemantic proximity Read

Inhibitors of Mitochondrial Fission as a Therapeutic Strategy for Diseases with Oxidative Stress and Mitochondrial DysfunctionSemantic proximity Read

Mitochondrial fission, fusion, and stress.Semantic proximity Read

Benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide induces human trophoblast Swan 71 cell dysfunctions due to cell apoptosis through disorder of mitochondrial fission/fusionSemantic proximity Read

Fusion and fission: interlinked processes critical for mitochondrial health.Semantic proximity Read

Placental Mitochondrial Abnormalities in PreeclampsiaSemantic proximity Read

Trophoblast syncytialisation necessitates mitochondrial function through estrogen-related receptor- activationSemantic proximity Read

Identification of Elongation Factor-2 as a Novel Regulator of Mitochondrial FissionSemantic proximity Read

Cannabidiol Disrupts Mitochondrial Respiration and Metabolism and Dysregulates Trophoblast Cell DifferentiationSemantic proximity Read

Mitochondrial hyperfusion: a friend or a foe.Semantic proximity Read

p66Shc-mediated oxidative stress is involved in gestational diabetes mellitusSemantic proximity Read

Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion ImbalanceSemantic proximity Read