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p66Shc-mediated oxidative stress is involved in gestational diabetes mellitus

15 Nov 2021

Abstract excerpt

BACKGROUND: Gestational diabetes mellitus (GDM) is associated with a heightened level of oxidative stress, which is characterized by the overproduction of reactive oxygen species (ROS) from mitochondria. Previous studies showed that mitochondrial dysfunction is regulated by dynamin-related protein 1 (Drp1) and p66Shc in GDM. AIM: The aim was to investigate the expression of Drp1 and p66Shc and their possible...

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PMID: 34888014
DOI: 10.4239/wjd.v12.i11.1894

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