Article
Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998
Blattner J, Helfert S, Michels P, Clayton C
Abstract excerpt
African trypanosomes compartmentalize glycolysis in a microbody, the glycosome. When growing in the mammalian bloodstream, trypanosomes contain only a rudimentary mitochondrion, and the first seven glycolytic enzymes, including phosphoglycerate kinase, are located in the glycosome. Procyclic tryp...
Topics
- Adenosine Triphosphate
- Animals
- Cell Compartmentation
- Energy Metabolism
- Gene Expression Regulation, Enzymologic
- Genes, Protozoan
- Glycolysis
- Mitochondria
- Mutation
- Oxidative Phosphorylation
- Phosphoglycerate Kinase
- Transfection
- Trypanosoma brucei brucei
- Trypanosomiasis, African