Article

1q21.3 amplification modulates therapy sensitivity in Triple Negative Breast Cancer

2020-05-01

Abstract excerpt

The contrast in therapy sensitivity and response across triple negative breast cancer (TNBC) patients suggest underlying genotypic heterogeneity. Using publicly available data, we found significant associations between DNA-level copy number alterations of 1q21.3 locus and therapy sensitivity. We show that in spite of their aggressive nature, 1q21.3 amplified tumors are more responsive to commonly used cytotoxic th...

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Literature Corpus work: 364529e8-4534-58e9-be71-f3fe45206e7d
DOI: 10.1101/2020.04.29.066993

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