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Article

Emerging Principles of Conformation-Based Prion Inheritance

11 Mar 2003

Abstract excerpt

The prion hypothesis proposes that proteins can act as infectious agents. Originally formulated to explain transmissible spongiform encephalopathies (TSEs), the prion hypothesis has been extended with the finding that several non-Mendelian traits in fungi are due to heritable changes in protein conformation, which may in some cases be beneficial. Although much remains to be learned about the specific role of...

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PMID: 15189155
DOI: 10.1146/annurev.biochem.72.121801.161837

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