Article

Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway

2021-08-20

Abstract excerpt

SARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs and farmed mink. Since the start of the 2019 pandemic several reverse zoonotic outbreaks of SARS-CoV-2 have occurred in mink, one of which reinfected humans and caused a cluster of infections in Denmark. Here we investigate the molecular basis of mink and ferret adaptation and demonstrate the spike mutations Y453F, F486L, and N501T all s...

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Literature Corpus work: 3601a6b6-663b-57dd-ad62-150db995dd92
DOI: 10.1101/2021.08.20.456972

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