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Article

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption.

PLoS pathogens - 1 Nov 2021

Ren Wenlin, Lan Jun, Ju Xiaohui, Gong Mingli, Long Quanxin, Zhu Zihui, Yu Yanying, Wu Jianping, Zhong Jin, Zhang Rong, Fan Shilong, Zhong Guocai, Huang Ailong, Wang Xinquan, Ding Qiang

Abstract excerpt

COVID-19 patients transmitted SARS-CoV-2 to minks in the Netherlands in April 2020. Subsequently, the mink-associated virus (miSARS-CoV-2) spilled back over into humans. Genetic sequences of the miSARS-CoV-2 identified a new genetic variant known as "Cluster 5" that contained mutations in the spike protein. However, the functional properties of these "Cluster 5" mutations have not been well established. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34748603
DOI: 10.1371/journal.ppat.1010053
PMCID: PMC8601601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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