Article
Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway.
Cell reports - 8 Feb 2022
Zhou Jie, Peacock Thomas P, Brown Jonathan C, Goldhill Daniel H, Elrefaey Ahmed M E, Penrice-Randal Rebekah, Cowton Vanessa M, De Lorenzo Giuditta, Furnon Wilhelm, Harvey William T, Kugathasan Ruthiran, Frise Rebecca, Baillon Laury, Lassaunière Ria, Thakur Nazia, Gallo Giulia, Goldswain Hannah, Donovan-Banfield I'ah, Dong Xiaofeng, Randle Nadine P, Sweeney Fiachra, Glynn Martha C, Quantrill Jessica L, McKay Paul F, Patel Arvind H, Palmarini Massimo, Hiscox Julian A, Bailey Dalan, Barclay Wendy S
Abstract excerpt
SARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs, and farmed mink. Since the start of the 2019 pandemic, several reverse zoonotic outbreaks of SARS-CoV-2 have occurred in mink, one of which reinfected humans and caused a cluster of infections in Denmark. Here we investigate the molecular basis of mink and ferret adaptation and demonstrate the spike mutations Y453F, F486L, and N501T...
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