Article

Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.

2021-08-23

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs and farmed mink. Since the start of the 2019 pandemic several reverse zoonotic outbreaks of SARS-CoV-2 have occurred in mink, one of which reinfected humans and caused a cluster of infections in Denmark. Here we investigate the molecular basis of mink and ferret adaptation and demonstrate the spike mutations Y...

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Literature Corpus work: 6269636d-4a40-5f4e-a9a8-b42593980cae
DOI: 10.21203/rs.3.rs-829214/v1

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