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Article

A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae.

Nature communications - 28 Jul 2015

Atack John M, Srikhanta Yogitha N, Fox Kate L, Jurcisek Joseph A, Brockman Kenneth L, Clark Tyson A, Boitano Matthew, Power Peter M, Jen Freda E-C, McEwan Alastair G, Grimmond Sean M, Smith Arnold L, Barenkamp Stephen J, Korlach Jonas, Bakaletz Lauren O, Jennings Michael P

Abstract excerpt

Non-typeable Haemophilus influenzae contains an N(6)-adenine DNA-methyltransferase (ModA) that is subject to phase-variable expression (random ON/OFF switching). Five modA alleles, modA2, modA4, modA5, modA9 and modA10, account for over two-thirds of clinical otitis media isolates surveyed. Here, we use single molecule, real-time (SMRT) methylome analysis to identify the DNA-recognition motifs for all five of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26215614
DOI: 10.1038/ncomms8828
PMCID: PMC4525171

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