Article

TSH Receptor Reduces Hemoglobin S Polymerization, Increases Deformability and Adhesion of Sickle Erythrocytes

2023-06-26

Abstract excerpt

<h4>Background: </h4> SCD is a hereditary disorder caused by genetic mutation in the beta-globin gene, resulting in abnormal hemoglobin, HbS, that forms sickle-shaped erythrocytes. Patients with SCD have endocrine disorders and it was described that 7% of these patients have clinical hypothyroidism. Recent studies have shown that mature erythrocytes possess TSH receptors. Thus, we aimed to assess the effects of TS...

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Literature Corpus work: 35d6c26b-b9bb-5703-a85d-9ed80788d50a
DOI: 10.21203/rs.3.rs-3083084/v1

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