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Article

Tucaresol increases oxygen affinity and reduces haemolysis in subjects with sickle cell anaemia

1 Jun 1996

Abstract excerpt

The primary pathophysiological event in sickling is the intracellular polymerization of deoxygenated haemoglobin S. Tucaresol (589C80;4[2-formyl-3-hydroxyphenoxymethyl] benzoic acid), a substituted benzaldehyde, was designed to interact with haemoglobin to increase oxygen affinity and has been shown to inhibit sickling in vitro. We administered tucaresol to sickle cell patients in the steady state to examine the...

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Identifiers

PMID: 8703810
DOI: 10.1046/j.1365-2141.1996.d01-1744.x

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