Article

Viral mediated tethering to SEL1L facilitates ER-associated degradation of IRE1

2020-10-09

Abstract excerpt

The unfolded protein response (UPR) and endoplasmic reticulum (ER)-associated degradation (ERAD) are two essential components of the quality control system for proteins in the secretory pathway. When unfolded proteins accumulate in the ER, UPR sensors such as IRE1 induce the expression of ERAD genes, thereby increasing protein export from the ER to the cytosol and subsequent degradation by the proteasome. Converse...

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Literature Corpus work: 27593e6b-f9a8-5451-a264-b9bc44eb4723
DOI: 10.1101/2020.10.07.330779

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