Article
Differential proteomic analysis of abnormal intramyoplasmic aggregates in desminopathy.
Journal of proteomics - 2 Sept 2013
Maerkens A, Kley R A, Olivé M, Theis V, van der Ven P F M, Reimann J, Milting H, Schreiner A, Uszkoreit J, Eisenacher M, Barkovits K, Güttsches A K, Tonillo J, Kuhlmann K, Meyer H E, Schröder R, Tegenthoff M, Fürst D O, Müller T, Goldfarb L G, Vorgerd M, Marcus K
Abstract excerpt
Desminopathy is a subtype of myofibrillar myopathy caused by desmin mutations and characterized by protein aggregates accumulating in muscle fibers. The aim of this study was to assess the protein composition of these aggregates. Aggregates and intact myofiber sections were obtained from skeletal muscle biopsies of five desminopathy patients by laser microdissection and analyzed by a label-free spectral...
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