Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapy-Induced Senescence in Cancer

22 Sept 2010

Abstract excerpt

Cellular senescence is a response to nonlethal stress that results in persistent cytostasis with a distinct morphological and biochemical phenotype. The senescence phenotype, detected in tumors through the expression of mRNA and protein markers, can be generated in cancer cells lacking functional p53 and retinoblastoma protein. Current research suggests that therapy-induced senescence (TIS) represents a novel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to Cytomegalovirus and herpesvirus research
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20858887
DOI: 10.1093/jnci/djq364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapy-Induced Senescence in CancerPMID 20858887Read ↗

Therapy-Induced Senescence: An “Old” Friend Becomes the EnemySemantic proximity Read ↗

Cellular senescence: a double-edged sword in cancer therapySemantic proximity Read ↗

Mechanisms and significance of therapy-induced and spontaneous senescence of cancer cellsSemantic proximity Read ↗

Role of senescence induction in cancer treatmentSemantic proximity Read ↗

Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectivesSemantic proximity Read ↗

Therapy-induced senescence as a component of tumor biology: Evidence from clinical cancerSemantic proximity Read ↗

The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced SenescenceSemantic proximity Read ↗

Exploiting tumor cell senescence in anticancer therapySemantic proximity Read ↗

Cellular senescence: a promising strategy for cancer therapySemantic proximity Read ↗

In brief: cell senescence.Semantic proximity Read ↗

Therapy-Induced Tumor Cell Senescence: Mechanisms and Circumvention.Semantic proximity Read ↗

Overcoming the senescence-associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.