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Species-specific vulnerability of RanBP2 shaped the evolution of SIV as it transmitted in African apes

8 Mar 2018

Abstract excerpt

HIV-1 arose as the result of spillover of simian immunodeficiency viruses (SIVs) from great apes in Africa, namely from chimpanzees and gorillas. Chimpanzees and gorillas were, themselves, infected with SIV after virus spillover from African monkeys. During spillover events, SIV is thought to require adaptation to the new host species. The host barriers that drive viral adaptation have predominantly been...

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PMID: 29518153
DOI: 10.1371/journal.ppat.1006906

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