Article

The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis

2022-06-15

Abstract excerpt

<h4>Background: </h4> Histamine is a critical mediator of anaphylaxis, a neurotransmitter, and a regulator of gastric acid secretion. Histidine decarboxylase is a rate-limiting enzyme for histamine synthesis. However, in vivo regulation of Hdc, the gene that encodes histidine decarboxylase is poorly understood. <h4>Objective:</h4> We sought to investigate how enhancers regulate Hdc gene transcription and histamine...

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Literature Corpus work: 34f8ce99-b6a5-5f06-b09d-3d4300a1b829
DOI: 10.1101/2022.06.13.495950

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