Article

Nanoscopic Quantification of Sub-mitochondrial Morphology, Mitophagy and Mitochondrial Dynamics in Patients With Mitochondrial Disease

2020-11-17

Abstract excerpt

<title>Abstract</title> <p><italic>SLC25A46</italic> mutations have been found to lead to mitochondrial hyper-fusion and reduced mitochondrial respiratory function, which results in optic atrophy, cerebellar atrophy, and other clinical symptoms of mitochondrial disease. However, it is generally believed that mitochondrial fusion is attributable to increased mitochondrial oxidative phosphorylation (OXPHOS)[1], whi...

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Literature Corpus work: 34f74782-ff5f-5edf-8d54-0b1beffd0379
DOI: 10.21203/rs.3.rs-105738/v1

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