Article

Mechanisms of hyperactivity and C-type inactivation in the diabetic-prone TALK1 L114P mutant potassium channel

2025-05-06

Abstract excerpt

<title>Abstract</title> <p>The gain-of-function TALK1-L114P mutation, associated with maturity-onset of diabetes of the young (MODY), inhibits insulin secretion via suppressing pancreatic β-cell excitability. However, the structural mechanisms underlying this pathological hyperactivity have remained unclear. By combining molecular dynamics (MD) simulations and electrophysiological analysis, we show that the L114P...

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Literature Corpus work: 34c91bf6-dfb7-5eba-b2f2-5e623178ca78
DOI: 10.21203/rs.3.rs-6526785/v1

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