Article

Modulating the proliferative and cytotoxic properties of human TIL by a synthetic immune niche of immobilized CCL21 and ICAM1

2022-07-07

Abstract excerpt

The major challenge in developing an effective adoptive cancer immunotherapy, is the ex-vivo generation of tumor-reactive cells, in sufficient numbers and with enhanced cytotoxic potential. It was recently demonstrated, that culturing of activated murine CD8+ T-cells on a “Synthetic Immune Niche” (SIN), consisting of immobilized CCL21 and ICAM-1, enhances T-cell expansion, increases cytotoxicity against cultured...

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Literature Corpus work: 348b52c9-8236-5f6f-9c97-2309c77113f7
DOI: 10.1101/2022.07.07.499105

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