Article
Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2015
Chacon Jessica Ann, Sarnaik Amod A, Chen Jie Qing, Creasy Caitlin, Kale Charuta, Robinson John, Weber Jeffrey, Hwu Patrick, Pilon-Thomas Shari, Radvanyi Laszlo
Abstract excerpt
PURPOSE: Cultured tumor fragments from melanoma metastases have been used for years as a source of tumor-infiltrating lymphocytes (TIL) for adoptive cell therapy (ACT). The expansion of tumor-reactive CD8(+) T cells with interleukin-2 (IL2) in these early cultures is critical in generating clinically active TIL infusion products, with a population of activated 4-1BB CD8(+) T cells recently found to constitute the...
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