Article
IL-21 promotes the expansion of CD27+ CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells.
Journal of translational medicine - 12 Feb 2013
Santegoets Saskia J A M, Turksma Annelies W, Suhoski Megan M, Stam Anita G M, Albelda Steve M, Hooijberg Erik, Scheper Rik J, van den Eertwegh Alfons J M, Gerritsen Winald R, Powell Daniel J, June Carl H, de Gruijl Tanja D
Abstract excerpt
BACKGROUND: Adoptive cell transfer of tumor infiltrating lymphocytes has shown clinical efficacy in the treatment of melanoma and is now also being explored in other tumor types. Generation of sufficient numbers of effector T cells requires extensive ex vivo expansion, often at the cost of T cell differentiation and potency. For the past 20 years, IL-2 has been the key cytokine applied in the expansion of TIL for...
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