Article

Human gut Actinobacteria boost drug absorption by secreting P-glycoprotein ATPase inhibitors

2022-10-14

Abstract excerpt

<h4>SUMMARY</h4> Drug efflux transporters are a major determinant of drug efficacy and toxicity. A canonical example is P-glycoprotein (P-gp), an efflux transporter that controls the intestinal absorption of diverse compounds. Despite reports that P-gp expression depends on the microbiome, the mechanisms responsible and their physiological relevance remain unclear. Surprisingly, we found that the cardiac drug-met...

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Literature Corpus work: 34720734-b7d4-54e6-a10f-fb4af80bab0a
DOI: 10.1101/2022.10.13.512142

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