Influence of gut microbiota on oral drug absorption and metabolism

Abstract excerpt

<h4>ABSTRACT</h4> Gut bacteria influence host intestinal phenotype in ways that impact drug absorption and metabolism. By comparing colonic tissue from germ-free mice to that of mice colonized with human microbiota, this study evaluates microbiota-driven differences in gene expression, mucosal permeability, and P-gp efflux capacity. Transcriptomic analysis revealed upregulation of genes coding ATP-binding cassett...

Topics

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• Berberine and alkaloids research
• Cannabis and Cannabinoid Research
• Clostridium difficile and Clostridium perfringens research
• Drug Transport and Resistance Mechanisms
• Ginseng Biological Effects and Applications
• Gut microbiota and health
• Oral health in cancer treatment
• Pharmacogenetics and Drug Metabolism

Identifiers and source

Literature Corpus work

d8dae432-a7e9-5e40-a073-7f55e28d61cc

DOI

10.1101/2025.02.16.638186