The Chemokine Receptor CCR8 is Not a High-affinity Receptor for the Human Chemokine CCL18

Abstract excerpt

<h4>ABSTRACT</h4> The primate-specific chemokine CCL18 is a potent chemoattractant for T cells and is expressed at elevated levels in several inflammatory diseases. However, the cognate receptor for CCL18 remains unconfirmed. Here, we describe attempts to validate a previous report that the chemokine receptor CCR8 is the human CCL18 receptor (Islam et al. J Exp Med. 2013, 210 :1889-98). Two mouse pre-B cell lin...

Topics

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• Chemokine receptors and signaling
• Computer Simulation
• Drug Design
• Immunotherapy and Immune Responses
• Ligands
• Mutation
• Receptors, Chemokine
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

345a89cd-5073-50fe-99fb-7645292074da

DOI

10.1101/2024.05.30.596614