Article

JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton

2020-06-24

Abstract excerpt

Lysosome axonal transport is important for the clearance of cargoes sequestered by the endocytic and autophagic pathways. Building on observations that mutations in the JIP3 ( MAPK8IP3 ) gene result in lysosome-filled axonal swellings, we analyzed the impact of JIP3 depletion on the cytoskeleton of human neurons. Dynamic focal lysosome accumulations were accompanied by disruption of the axonal periodic scaffold (...

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Literature Corpus work: 345a7e8e-8d69-50cf-b537-3fe9c50bb654
DOI: 10.1101/2020.06.24.169219

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