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Article

Peripheral neuropathies caused by mutations in the myelin protein zero.

Journal of the neurological sciences - 15 Mar 2006

Shy Michael E

Abstract excerpt

Charcot-Marie-Tooth disease type 1B (CMT1B) is caused by mutations in the major PNS myelin protein myelin protein zero (MPZ). MPZ is a member of the immunoglobulin supergene family and functions as an adhesion molecule helping to mediate compaction of PNS myelin. Mutations in MPZ appear to either disrupt myelination during development, leading to severe early onset neuropathies, or to disrupt axo-glial...

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Source

Identifiers

PMID: 16414078
DOI: 10.1016/j.jns.2005.11.015

Genes

MPZ

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Peripheral neuropathies caused by mutations in the myelin protein zero.PMID 16414078Read ↗

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