Article

CagY-dependent regulation of type IV secretion in <i>Helicobacter pylori</i> is associated with alterations in integrin binding

2018-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Strains of Helicobacter pylori that cause ulcer or gastric cancer typically express a type IV secretion system (T4SS) encoded by the cag pathogenicity island (PAI). CagY is an ortholog of VirB10 that, unlike other VirB10 orthologs, has a large middle repeat region (MRR) with extensive repetitive sequence motifs, which undergo CD4+ T cell-dependent recombination during infection of mice. Recomb...

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Literature Corpus work: 3446eaf8-27de-5b02-b3b5-2edc1617f4c3
DOI: 10.1101/294769

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