Article

Asparagine couples group A <i>Streptococcal</i> metabolism to virulence

2024-07-08

Abstract excerpt

Streptococcus (GAS) is a highly adapted and human-restricted pathogen causing a wide variety of infections, some life-threatening 1 . This ability is linked to the expression of many virulence factors, whose transcription is regulated by the two-component system, CovR/S 2–5 . Here, we show that genome transcription of GAS cultured in a chemically defined medium (CDM) is globally affected when supplemented with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3430e62c-e0e6-56f1-9ecc-1f6e9906d6ec
DOI: 10.1101/2024.07.08.602371

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Asparagine couples group A <i>Streptococcal</i> metabolism to virulenceDOI 10.1101/2024.07.08.602371Read

Group A Streptococcal asparagine metabolism regulates bacterial virulenceSemantic proximity Read

Genome-Wide Identification of Essential Genes in the Invasive <i>Streptococcus anginosus</i> StrainSemantic proximity Read

Multi-omics profiling reveals atypical sugar utilization and identifies a key membrane composition regulator in <i>Streptococcus pneumoniae</i>Semantic proximity Read

Ectopic expression of the sensor CovS cytosolic domain confers phosphatase activity and full virulence to the M1T1 CovSY39H attenuated variant of group A <i>Streptococcus</i>Semantic proximity Read

BrnQ-type Branched-chain Amino Acid Transporters Influence <i>Bacillus anthracis</i> Growth and VirulenceSemantic proximity Read

Harnessing subtractive genomics for drug target identification in <i>Streptococcus agalactiae</i> serotype v (atcc baa-611 / 2603 v/r) strain: An <i>in-silico</i> approachSemantic proximity Read

A direct link between carbohydrate utilization and virulence in the major human pathogen group A <i>Streptococcus</i>Semantic proximity Read

Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surfaceSemantic proximity Read

Citrulline protects Streptococcus pyogenes from acid stress using the arginine deiminase pathway and the F1Fo-ATPase.Semantic proximity Read

Structure, Substrate Complexation and Reaction Mechanism of Bacterial AsparaginasesSemantic proximity Read

Global gene expression analysis of <i>Streptococcus agalactiae</i> at exponential growth phaseSemantic proximity Read

Asparagine synthetase: Function, structure, and role in disease.Semantic proximity Read