Article

Identifying potential regulators of JAGGED1 expression in portal mesenchymal cells.

2022-02-17

Abstract excerpt

<title>Abstract</title> <p><bold>Objective:</bold> Portal mesenchymal cells induces the epithelial differentiation of the bile ducts in the developing liver via one of the Delta-Notch signaling components, JAGGED1. Although this differential induction is crucial for normal liver physiology as its genetic disorder (Alagille syndrome) causes jaundice, the molecular mechanism behind JAGGED1 expression remain unknown...

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Literature Corpus work: 3414d24e-2792-5fef-9da1-fc0b10b27209
DOI: 10.21203/rs.3.rs-1210544/v1

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