Article

A network of microRNAs acts to promote cell cycle exit and differentiation of human pancreatic endocrine cells

2019-04-25

Abstract excerpt

<h4>SUMMARY</h4> Pancreatic endocrine cell differentiation is orchestrated by transcription factors that operate in a gene regulatory network to activate endocrine lineage genes and repress lineage-inappropriate genes. MicroRNAs (miRNAs) are important modulators of gene expression, yet their role in endocrine cell differentiation has not been explored system-wide. Here we characterize miRNA-regulatory networks ac...

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Literature Corpus work: 6f77e14d-55c8-5a46-93fd-4cf944b1a0b4
DOI: 10.1101/618330

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