Article

Taming strong selection with large sample sizes

2021-03-30

Abstract excerpt

1 The fate of mutations and the genetic load of populations depend on the relative importance of genetic drift and natural selection. In addition, the accuracy of numerical models of evolution depends on the strength of both selection and drift: strong selection breaks the assumptions of the nearly neutral model, and drift coupled with large sample sizes breaks Kingman’s coalescent model. Thus, the regime with str...

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Literature Corpus work: 33eec3a4-6b9b-595a-a80a-e1d5d011a79e
DOI: 10.1101/2021.03.30.437711

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