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Passenger mutations accurately classify human tumors

15 Apr 2019

Abstract excerpt

Determining the cancer type and molecular subtype has important clinical implications. The primary site is however unknown for some malignancies discovered in the metastatic stage. Moreover liquid biopsies may be used to screen for tumoral DNA, which upon detection needs to be assigned to a site-of-origin. Classifiers based on genomic features are a promising approach to prioritize the tumor anatomical site, type...

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PMID: 30986244
DOI: 10.1371/journal.pcbi.1006953

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