Article

Mrs4 loss of function in fungi during adaptation to the cystic fibrosis lung

2023-04-06

Abstract excerpt

The genetic disease cystic fibrosis (CF) frequently leads to chronic lung infections by bacteria and fungi. We identified three individuals with CF with persistent lung infections dominated by Clavispora ( Candida ) lusitaniae . Whole genome sequencing analysis of multiple isolates from each infection found evidence for selection for mutants in the gene MRS4 in all three distinct lung-associated populations. I...

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Literature Corpus work: 33d12c99-2dc0-50ed-8fa8-a0735aefee80
DOI: 10.1101/2023.04.05.535776

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