Article

Decoding glycosylation potential from protein structure across human glycoproteins with a multi-view recurrent neural network

2024-05-15

Abstract excerpt

Glycosylation is described as a non-templated biosynthesis. Yet, the template-free premise is antithetical to the observation that different N-glycans are consistently placed at specific sites. It has been proposed that glycosite-proximal protein structures could constrain glycosylation and explain the observed microheterogeneity. Using site-specific glycosylation data, we trained a hybrid neural network to parse...

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Literature Corpus work: 33bb944c-cb6a-5b94-80f7-f491aa587b89
DOI: 10.1101/2024.05.15.594334

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