Article
Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency.
Science (New York, N.Y.) - 24 Apr 2015
Ciancanelli Michael J, Huang Sarah X L, Luthra Priya, Garner Hannah, Itan Yuval, Volpi Stefano, Lafaille Fabien G, Trouillet Céline, Schmolke Mirco, Albrecht Randy A, Israelsson Elisabeth, Lim Hye Kyung, Casadio Melina, Hermesh Tamar, Lorenzo Lazaro, Leung Lawrence W, Pedergnana Vincent, Boisson Bertrand, Okada Satoshi, Picard Capucine, Ringuier Benedicte, Troussier Françoise, Chaussabel Damien, Abel Laurent, Pellier Isabelle, Notarangelo Luigi D, García-Sastre Adolfo, Basler Christopher F, Geissmann Frédéric, Zhang Shen-Ying, Snoeck Hans-Willem, Casanova Jean-Laurent
Abstract excerpt
Severe influenza disease strikes otherwise healthy children and remains unexplained. We report compound heterozygous null mutations in IRF7, which encodes the transcription factor interferon regulatory factor 7, in an otherwise healthy child who suffered life-threatening influenza during primary infection. In response to influenza virus, the patient's leukocytes and plasmacytoid dendritic cells produced very...
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